Salah satu upaya untuk mencegah penularan COVID-19, pemerintah Kota Depok melakukan program vaksinasi COVID-19. Capaian vaksinasi COVID-19 Kota Depok sampai tanggal 22 Juli  2021 mencapai 8,07% di mana belum mencapai target. Pencapaian program bergantung pada penerimaan sasaran program vaksinasi COVID-19. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan penerimaan vaksin COVID-19 di Kota Depok. Penelitian ini merupakan penelitian kuantitatif dengan desain cross sectional. Sampel pada penelitian ini adalah masyarakat Kota Depok yang berusia 18 tahun keatas, tinggal di Kota Depok dan belum mendapatkan vaksin COVID-19. Jumlah sampel dalam penelitian ini sebanyak 256 responden. Metode sampling yang digunakan adalah consecutive sampling. Pengumpulan data menggunakan google form. Analisis data yang digunakan adalah univariat dengan menggunakan tabel distribusi frekuensi, analisis bivariat menggunakan chi square dan analisis multivariat menggunakan resgresi logistik ganda. Hasil penelitian menunjukkan bahwa sebesar  176 responden (68,7%) menerima vaksin COVID-19. Hasil uji statistik menunjukkan bahwa terdapat hubungan antara umur, persepsi keparahan, persepsi manfaat, persepsi hambatan dan dukungan keluarga dengan penerimaan vaksin COVID-19. Dan tidak ada hubungan antara jenis kelamin, pendidikan, pekerjaan, persepsi kerentanan, isyarat bertindak, keterpaparan media informasi, riwayat penyakit komorbid, riwayat terinfeksi COVID-19, pengetahuan tentang COVID-19 dan vaksin COVID-19, serta riwayat vaksinasi influenza dengan penerimaan vaksin COVID-19.

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One of the efforts to prevent the transmission of COVID-19, the Depok City government carried out a COVID-19 vaccination program. Depok City's COVID-19 vaccination achievement until July 22, 2021 reached 130.077 (8,06%) which had not yet reached the vaccination target. Achievement of the program is contingent on the acceptance of the targeted COVID-19 vaccination program. The purpose of this study was to determine the factors associated with receiving the COVID-19 vaccine in Depok City. This research is a quantitative research withdesign cross sectional. The sample in this study was Depok City people aged 18 years and over, living in Depok City and had not received the COVID-19 vaccine. The sample in this study were 256 respondents. The sampling method used is consecutive sampling. Data collection using google form. The data analysis used was univariate using a frequency distribution table, bivariate analysis using chi square and multivariate analysis using multiple logistic regression. The results showed that 176 respondents (68,7%( received he COVID-19 vaccine, The results showed that there was a relationship between age, perceived severity, perceived benefits, perceived barriers and family support with COVID-19 vaccine acceptance.