Isatin (indoline-2,3-dione atau indole -1H-2,3-dione merupakan produk alami yangbanyak ditemukan pada tanaman yang bergenus Isatis dan pada Couropitaguiananci aub. Isatin dan senyawa turunannya memiliki berbagai aktivitas biologisseperti senyawa anti kanker, anti jamur, anti oksidan, anti diabetes, anti HIV,pelindung saraf, anti inflamasi, analgesik. Pada penelitian ini, dilakukan prosessintesis dari senyawa turunan isatin dengan berbagai variasi prekusor danpenggunaan MgCl2 sebagai katalis. Prekusor utama yang digunakan dalampenelitian ini adalah Isatin dan Lawson (1,4 naphtoquinon) serta variasiprekusornya berupa malononitril, hidrazin, fenil hidrazin, dan etil asetoasetat. Hasilsintesis dari masing-masing variasi diisolasi untuk mendapatkan produk murni dandilakukan karakterisasi FT-IR. Untuk karakterisasi NMR dilakukan hanya untukproduk variasi 1 dan variasi 3. Massa produk yang didapatkan setelah diisolasiyakni variasi 1 sebesar 0.0378 gram; variasi 2 sebesar 0.0232 gram; variasi 3sebesar 0.0494 gram; variasi 4 sebesar 0.0266 gram. Berdasarkan hasil NMR yangdilakukan, produk variasi 1 dan variasi 3 bukan merupakan produk yangdiharapkan. Prediksi struktur dari produk variasi 1 memiliki rumus molekulC11H7N3O dengan m/z 197

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Isatin (indoline-2,3-dione or indole -1H-2,3-dione) is a natural product which is

found in many plants with the genus name of Isatis and in Couropita guiananci

aub. Isatin and its derivatives have various biological activities such as anti-cancer,

anti-fungi, anti-oxidants, anti-diabetes, anti-HIV, neuroprotective, antiinflammatory,

and analgesic. In this study, the synthesis process of isatin

derivatives with various precursors was carried out and the use of MgCl2 as a

catalyst. The main precursors used in this study were Isatin and Lawson (1,4

naphtoquinone) and its precursor variations in the form of malononitrile, hydrazine,

phenyl hydrazine, and ethyl acetoacetate. The synthesis results of each variation

were isolated to obtain a pure product and performed FT-IR characterization. and

variation 3. The mass of the product obtained after being isolated for variation 1 is

0.0378 grams; variation 2 is 0.0232 grams; variation 3 is 0.0494 grams; and

variation 4 is 0.0266 grams. Based on the results of the NMR, the product of

variation 1 and variation 3 was not the expected product. The predicted structure of

the product variation 1 has the molecular formula C11H7N3O with m / z 197