ABSTRAK Permasalahan DM bersifat kompleks dan berbagai intervensi telah dilakukan dalam pencegahan dan pengendalian komplikasi namun hasilnya belum optimal. Berdasarkan hal tersebut, penulis ingin mengidentifikasi pengaruh pelaksanaan intervensi budaya keperawatan diabetes dalam pencegahan dan pengendalian komplikasi pada agregat dewasa di Kelurahan Curug Kecamatan Cimanggis Kota Depok dengan metode praktik keperawatan berbasis fakta EBNP dengan inovasi intervensi budaya keperawatan. Studi ini dilakukan pada 44 responden dewasa DM, 10 keluarga dan 30 kader kesehatan yang berpartisipasi aktif dalam pelaksanaan inovasi ini. Hasil diperoleh ada perbedaan yang bermakna kadar gula darah dan kemandirian dengan pendekatan budaya setelah diberikan intervensi. Intervensi budaya keperawatan berpengaruh terhadap kadar gula darah dan kemandirian dewasa DM dalam pengelolaan penyakitnya. Disimpulkan bahwa intervensi budaya keperawatan menurunkan kadar gula darah dan meningkatkan kemandirian dewasa DM serta memberi peluang perawat mengembangkan upaya promotif maupun preventif. Direkomendasikan perlunya kebijakan yang mengintegrasikan intervensi budaya keperawatan dalam program pencegahan PTM atau posbindu PTM.Kata kunci : Dewasa, Intervensi Budaya Keperawatan, Kadar gula Darah, Kemandirian dan metode praktik keperawatan berbasis fakta EBNP ABSTRACT Diabetes problem is complex and various interventions have been done in the prevention and control of complications but the results are not optimal. Based on this, the study to know implementation of integrated nursing culture intervention model with COSEHI coaching and self-hypnosis to prevention and control of diabetes complications in adult aggregate in Curug, Cimanggis, Depok with the evidence based nursing practice EBNP as a method inovation nursing culture intervention. This study was done to 44 diabetes adult respondents, 10 families and 30 social workers that participate in intervention. The results were significant differences in blood sugar level and independence with a cultural approach after being given this intervention. Nursing Intervention culture was affect the blood sugar and adult DM independence in the management of the disease. It was concluded that nursing cultural intervention decreased blood sugar level and increased adult with diabetes independence and gave nurse opportunity to develop promotion and preventive effort. It is recommended that policies that integrate nursing culture interventions in prevention programs of PTM or posbindu.Keywords : Adult, nursing culture intervention model glicemic control, independence and the evidence based nursing practice EBNP