ABSTRAK Perawat spesialis neurosains berperan dalam praktik keperawatan berupa pemberi asuhan keperawatan lanjut, melakukan pembuktian ilmiah dan agen pembaharu. Asuhan keperawatan dilakukan pada kasus pasien dengan cedera kepala dan 30 pasien gangguan neurologis dengan pendekatan Model adaptasi Roy. Perilaku maladaptif paling banyak terganggu pada mode fisologis dengan diagnosa resiko ketidakefektifan perfusi jaringan serebral. Evidence Based Nursing dilakukan dengan menerapkan augmentative and alternative communication AAC pada 3 pasien stroke yang mengalami afasia motorik dengan hasil yang signifikan p value 0,038 . Program inovasi menerapkan enam screening tools yaitu Insomnia Severity Index ISI , National Institute Health Stroke Scale NIHSS , 3 Incontinence Question 3 IQ , Berg Balance Scale BBS , Frenchay Aphasia Screening Test FAST dan Adult Non Verbal Pain Scale ANVPS pada pasien dengan gangguan neurologi yang terbukti memudahkan perawat dalam menegakkan diagnosa keperawatan yang tepat. Model Adaptasi Roy telah berpengaruh besar terhadap profesi keperawatan. Model ini adalah salah satu model yang paling banyak digunakan dalam memandu penelitian, pendidikan dan praktik keperawatan. ABSTRACT Neuroscience nurse specialist play role in nursing practice as advanced nursing care providers, conduct scientific evidence and innovator. Roy adaptation model approach was used in the nursing care of the head injury patients and 30 patients of neurological disorders cases. Risk of cerebral tissue perfusion ineffectiveness was the most often of nursing diagnosis enforced which was caused maladaptive behavior in physiological mode. Evidence based nursing was implemented by augmentative and alternative communication AAC in 3 stroke patients with motor aphasia with significant results p value 0.038 . The Innovation program applies six screening tools are Insomnia Severity Index ISI , National Institute of Health Stroke Scale NIHSS , 3 Incontinence Questions 3 IQs , Berg Balance Scale BBS , Frenchay Aphasia Screening Test FAST and Adult Non Verbal Pain Scale ANVPS in neurological disorders patients proven to facilitate nurses in establishing nursing diagnoses. Roy Adaptation Model has greatly influenced the profession of nursing. It is one of the most frequently used models to guide nursing research, education and practice.