Psychology has had a long history of collaboration with the medical profession. This collaboration has been greatly enhanced over the past decade or more as an increasing number of psychologists have become successful in applying the science and practice of psychology to the problems of health and illness. This article reviews and summarizes salient aspects of professional issues in practice that contribute to successful collaboration with physicians in primary and tertiary ambulatory health care settings. Practical strategies to enhance collaboration in independent practice are discussed. (APA PsycInfo Database Record (c) 2016 APA, all rights reserved)