This article is focused on systematic explanation of Abraham Kuyper's though on calvinism and science. Some of significant contributions of calvinism are the theological foundation of science and its liberation from church's invasion. This article uses a philosophical approach in its methodology and not a theological one. Therefore, I frequently make critical dialogues with the philosophy of science in reading and analyzing Kuyper's Nation. Final ending of this research is an articulation of its implications to the ethics of science. On this point, I will consider the contribution of David Resnick