ABSTRAK Latar belakang Glaukoma masih merupakan salah satu penyebab kebutaan
terbesar di dunia. Belakangan ini, ketebalan RFNL dan GCIPL diketahui memiliki
hubungan terhadap perubahan struktural yang disebabkan oleh glaukoma.
Tujuan untuk mengkaji kemampuan diagnostik dari pengukuran ketebalan RFNL
dan GCIPL dalam mendeteksi glaukoma pada tahap awal.
Metode Enam puluh empat mata dengan sudut bilik mata sempit (32 glaukoma,
32 non-glaukoma) dari 48 pasien menjalani pengukuran menggunakan Cirrus
OCT dengan protokol 3,4 mm pemindaian cepat RFNL peripapilar. Pengukuran
dilakukan pada sisi superior, inferior, nasal, temporal dari GCIPL dan RFNL,
begitu juga dengan GCIPL superotemporal, superonasal, inferotemporal,
inferonasal, dan minimal.
Hasil Semua parameter yang diuji pada studi ini menunjukkan angka yang lebih
rendah pada kelompok PACG dibandingkan kelompok PAC. Rerata ketebalan
RFNL dan ketebalan GCIPL inferotemporal masing-masing memiliki nilai
spesifitias dan sensitifitas yang paling baik. Parameter dengan determinan terbaik
adalah ketebalan GCIPL inferotemporal dengan sensitifitas dan spesifitas masingmasing
75%
dan
75%.
Kesimpulan
Ketebalan GCIPL dan RFNL peripapil memiliki potensi besar
sebagai parameter diagnostik seperti skrining dan evaluasi respon terapi.
ABSTRACT Background Glaucoma remains one of the biggest causes of blindness
worldwide. Recently, RFNL and GCIPL thickness were shown to be correlated
with early structural changes caused by glaucoma.
Objective to evaluate the diagnostic performance of RFNL and GCIPL thickness
measurement in detecting early glaucoma
Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)
of
48
patients underwent peripapillar scanning using Cirrus OCT
using 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurement
includes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well as
superotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL.
Result All parameters studied were significantly thinner in PACG group
compared to PAC group. Mean RFNL thickness and inferotemporal GCIPL has
the highest specificity and sensitivity, respectively, in detecting glaucoma.
Parameter with the best determinant is inferotemporal GCIPL thickness with
sensitivity and specificity, 75% and 71.9%, respectively.
Conclusion Peripapillary RFNL and GCIPL could be a potential diagnostic
parameter in detecting early glaucoma and monitoring therapy response in
glaucoma patients. ;Background Glaucoma remains one of the biggest causes of blindness
worldwide. Recently, RFNL and GCIPL thickness were shown to be correlated
with early structural changes caused by glaucoma.
Objective to evaluate the diagnostic performance of RFNL and GCIPL thickness
measurement in detecting early glaucoma
Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)
of
48
patients underwent peripapillar scanning using Cirrus OCT
using 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurement
includes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well as
superotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL.
Result All parameters studied were significantly thinner in PACG group
compared to PAC group. Mean RFNL thickness and inferotemporal GCIPL has
the highest specificity and sensitivity, respectively, in detecting glaucoma.
Parameter with the best determinant is inferotemporal GCIPL thickness with
sensitivity and specificity, 75% and 71.9%, respectively.
Conclusion Peripapillary RFNL and GCIPL could be a potential diagnostic
parameter in detecting early glaucoma and monitoring therapy response in
glaucoma patients. ;Background Glaucoma remains one of the biggest causes of blindness
worldwide. Recently, RFNL and GCIPL thickness were shown to be correlated
with early structural changes caused by glaucoma.
Objective to evaluate the diagnostic performance of RFNL and GCIPL thickness
measurement in detecting early glaucoma
Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)
of
48
patients underwent peripapillar scanning using Cirrus OCT
using 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurement
includes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well as
superotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL.
Result All parameters studied were significantly thinner in PACG group
compared to PAC group. Mean RFNL thickness and inferotemporal GCIPL has
the highest specificity and sensitivity, respectively, in detecting glaucoma.
Parameter with the best determinant is inferotemporal GCIPL thickness with
sensitivity and specificity, 75% and 71.9%, respectively.
Conclusion Peripapillary RFNL and GCIPL could be a potential diagnostic
parameter in detecting early glaucoma and monitoring therapy response in
glaucoma patients.
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