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Efek antihiperlipidemia ekstrak etanol 80% kucai (Allium schoenoprasum L.) pada tikus putih jantan yang diberi diit tinggi kolesterol dan lemak = Antihyperlipidemic effect of 80% ethanol extract of chives (Allium schoenoprasum L.) in white male rats induced by high cholesterol and fat diet / Irsalina Nurul Putri

Irsalina Nurul Putri; Adhyatma Abbas; Azizahwati, supervisor; Anton Bahtiar, examiner; Rissyelly, examiner (, 2014)
URI : http://lontar.ui.ac.id/detail?id=20386394&lokasi=lokal
 Abstract
ABSTRACT

Hiperlipidemia adalah peningkatan salah satu atau lebih dari kolesterol, kolesterol
ester, fosfolipid, atau trigliserida. Allium schenoprasum L. merupakan tanaman satu
genus dari Allium sativum yang sudah teruji efek hiperlipidemianya. Penelitian ini
bertujuan untuk mengetahui efek antihiperlipidemia ekstrak etanol 80% kucai
(Allium schoenoprasum L.) pada tikus jantan yang diberi diit tinggi kolesterol dan
lemak. Sebanyak 36 tikus putih jantan galur Sparague dawley dibagi secara acak ke
dalam 6 kelompok perlakuan, yaitu kelompok normal, induksi, simvastatin, dan 3
kelompok dosis. Semua kelompok diberi diit tinggi kolesterol dan lemak kecuali
kelompok normal. Kelompok normal hanya diberikan CMC 0,5%. Setelah 1 jam
pemberian diit tinggi kolesterol dan lemak, kelompok induksi, simvastatin, dosis 1,
dosis 2, dan dosis 3 secara berturut-turut diberikan larutan CMC 0,5%, simvastatin
1,8 mg/200 g bb, ekstrak kucai 4,79 mg, 9,58 mg, dan 19,16 mg/200 g bb. Setelah 56
hari perlakuan, sampel darah tikus diambil melalui sinus orbital dan dilakukan
penetapan kadar kolesterol total, trigliserida, HDL, dan LDL pada plasma darah
tikus. Hasil penelitian menunjukkan bahwa ekstrak etanol 80% umbi kucai memiliki
efek antihiperlipidemia pada dosis 9,58 mg/200 g bb dilihat dari penurunan kadar
kolesterol total, trigliserida, dan LDL dan memberikan hasil berbeda bermakna
dibandingkan dengan kelompok induksi (p <0,05).


ABSTRACT

Hyperlipidemia is defined as an elevation of one or more of cholesterol, cholesterol
esters, phospholipids, or triglycerides. Allium schoenoprasum L. is a plant of the
same genus with Allium sativum which had been proven to have effect as
antihyperlipidemia. This study aimed to evaluate antihyperlipidemic effects of 80%
ethanolic extract of chives (Allium schoenoprasum L.) in male rats induced by high
cholesterol and fat diet. Thirty-six male rats of Sprague dawley strain were divided
randomly into 6 groups, those were normal group, induction group, simvastatin
group, and three dose groups. All groups except the normal group were given high
dietary cholesterol and fat. The normal group was given only 0,5 % CMC solution.
After one hour of high dietary cholesterol and fat administration, the induction
group, simvastatin group, dose I group, dose II group, and dose III group were given
0,5% CMC solution, 1,8 mg/200 g bw simvastatin, 4,79 mg/200 g bw, 9,58 mg/200 g
bw, and 19,16 mg/200 g bw chives extract as follows. Blood samples were collected
by the orbital sinus after 56 days of treatment to be analysed for total cholesterol,
triglycerides, HDL, and LDL. The results showed that 80% ethanolic extract of bulbs
chives have antihyperlipidemic effects at dose of 9,58 mg/200 g bw proven by
significant (p < 0,05) decreases in total cholesterol, triglycerides, and LDL compared
to induction group.
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 Metadata
Call Number : S55236
Author :
Other author/contributor :
Subject :
Publishing : [Place of publication not identified]: [Publisher not identified], 2014
Study Program :
Concise Text :
Cataloguing Source : LibUI ind rda
Content Type : text (rdacontent)
Media Type : unmediated (rdamedia); computer (rdamedia)
Carrier Type : volume (rdacarrier); online resource (rdacarrier)
Physical Description : xv, 59 pages : illustration ; 30 cm + appendix
Bibliographical Notes : pages 56-59
Holding Institution : Universitas Indonesia
Location : Perpustakaan UI, Lantai 3
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