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Efektifitas kombinasi ekstrak acalypha indica linn dan centella asicatica pada sel neuron piknotik di girus dentatus internus tikus sprague dawley pascahipoksia = The effectivity of combination extract acalypha indica linn and centella asiatica on picnotic cells in gyrus dentatus internus in sprague dawley rats pascahypoxia

Ermono Superaya; Siti Farida, supervisor; Siti Farida, examiner; Ari Estuningtyas, examiner (, 2013)
 Abstrak
[ABSTRAK

Stroke adalah suatu penyakit serebrovaskular yang disebabkan oleh berhentinya
aliran darah arteri ke otak. Sekitar 80-85% stroke adalah stroke iskemik yang
disebabkan oleh obstruksi pada arteri di sirkulasi serebelum. Hipoksia serebral
yang terjadi akibat iskemik pada otak tersebut menimbulkan perubahan pada
morfologi sel dan kemudian kematian sel dimana sel neuron menjadi piknotik
bermanifestasi berupa kecacatan neurologis pada penderitanya, sehingga penderita
stroke harus mengonsumsi obat jangka panjang untuk kesembuhannya. Citicoline
merupakan obat yang efektif untuk stroke dari penelitiannya namun memiliki
kelemahan dari segi pemakaian dan harga yang mahal menyebabkan obat ini
kurang efisien di masyarakat. Tanaman herbal akar kucing dan pegagan
merupakan obat alternatif pada terapi stroke karena efek neuroprotektifnya. Dosis
kombinasi kedua herbal ini diharapkan mampu memberikan perubahan jumlah
pada sel piknotik di otak.
Penelitian ini bersifat eksperimental dengan melakukan percobaan pemberian
ekstrak akar kucing dan pegagan terhadap tikus terhadap 5 kelompok tikus yang
dibuat hipoksia dengan berbagai jenis perlakuan yaitu pemberian akuades,
citicolin, dosis akar kucing 150,200,250mg dikombinasikan dengan pegagan
150mg. Serebelum tikus kemudian diambil dan dibuat sediaan preparat
histopatologi untuk dilihat perubahan terhadap sel piknotik di girus dentatus
internus.
Dari hasil uji One away Anova didapatkan bahwa tidak terdapat perubahan
jumlah sel piknotik yang bermakna terhadap perlakuan yang diberikan terhadap
tikus (p> 0,05). Pada penelitian ini dapat disimpulkan bahwa terapi kombinasi
kedua herbal tersebut tidak memberikan perubahan jumlah sel piknotik pada girus
dentatus internus tikus.


ABSTRACT

Stroke is cerebrovascular disease caused by cessation of arterial blood flow to the
brain. Approximately 80-85% of strokes are ischemic strokes caused by arterial
obstruction in the circulation of cerebellum. Cerebral hypoxia caused by ischemia
of the brain gives result in alteration of cells morphology and cell death in which
neuron cells become picnotics. This will later manifests in the form of
neurological disability shown in the affected individuals resulting in the need to
take long term medication. Citicoline is an effective drug for stroke based on
research but has drawbacks in term of usage and high price which cause it to be
less efficient in the community. The herbs cat root and Indian pennywort are
alternative drugs for stroke therapy because of its neuroprotective effects.
Combination dose of these two herbs are expected to provide a change in number
of picnotic cells in rat?s brain.
This research experiments on giving the extract of cat root and indian pennywort
to 5 groups of hypoxic rats in various dose (150, 200, 250 mg of cat root
combined with 150 mg of Indian pennyworts), negative control is given aquades
and positive control is given citicoline. The cerebellum of the rats is then taken
and is made to histopathologic preparation to see the changes of picnotic cells in
gyrus dentatus internus.
From the One Way Anova test results, it can be seen that there is no meaningful
changes in the number of picnotic cells after the treatments are given to the rats
(p>0,05). In conclusion, therapy with combination of cat root and Indian
pennywort does not provide changes in number of picnotic cells in gyrus dentatus
internus of the rats.;Stroke is cerebrovascular disease caused by cessation of arterial blood flow to the
brain. Approximately 80-85% of strokes are ischemic strokes caused by arterial
obstruction in the circulation of cerebellum. Cerebral hypoxia caused by ischemia
of the brain gives result in alteration of cells morphology and cell death in which
neuron cells become picnotics. This will later manifests in the form of
neurological disability shown in the affected individuals resulting in the need to
take long term medication. Citicoline is an effective drug for stroke based on
research but has drawbacks in term of usage and high price which cause it to be
less efficient in the community. The herbs cat root and Indian pennywort are
alternative drugs for stroke therapy because of its neuroprotective effects.
Combination dose of these two herbs are expected to provide a change in number
of picnotic cells in rat?s brain.
This research experiments on giving the extract of cat root and indian pennywort
to 5 groups of hypoxic rats in various dose (150, 200, 250 mg of cat root
combined with 150 mg of Indian pennyworts), negative control is given aquades
and positive control is given citicoline. The cerebellum of the rats is then taken
and is made to histopathologic preparation to see the changes of picnotic cells in
gyrus dentatus internus.
From the One Way Anova test results, it can be seen that there is no meaningful
changes in the number of picnotic cells after the treatments are given to the rats
(p>0,05). In conclusion, therapy with combination of cat root and Indian
pennywort does not provide changes in number of picnotic cells in gyrus dentatus
internus of the rats.;Stroke is cerebrovascular disease caused by cessation of arterial blood flow to the
brain. Approximately 80-85% of strokes are ischemic strokes caused by arterial
obstruction in the circulation of cerebellum. Cerebral hypoxia caused by ischemia
of the brain gives result in alteration of cells morphology and cell death in which
neuron cells become picnotics. This will later manifests in the form of
neurological disability shown in the affected individuals resulting in the need to
take long term medication. Citicoline is an effective drug for stroke based on
research but has drawbacks in term of usage and high price which cause it to be
less efficient in the community. The herbs cat root and Indian pennywort are
alternative drugs for stroke therapy because of its neuroprotective effects.
Combination dose of these two herbs are expected to provide a change in number
of picnotic cells in rat?s brain.
This research experiments on giving the extract of cat root and indian pennywort
to 5 groups of hypoxic rats in various dose (150, 200, 250 mg of cat root
combined with 150 mg of Indian pennyworts), negative control is given aquades
and positive control is given citicoline. The cerebellum of the rats is then taken
and is made to histopathologic preparation to see the changes of picnotic cells in
gyrus dentatus internus.
From the One Way Anova test results, it can be seen that there is no meaningful
changes in the number of picnotic cells after the treatments are given to the rats
(p>0,05). In conclusion, therapy with combination of cat root and Indian
pennywort does not provide changes in number of picnotic cells in gyrus dentatus
internus of the rats., Stroke is cerebrovascular disease caused by cessation of arterial blood flow to the
brain. Approximately 80-85% of strokes are ischemic strokes caused by arterial
obstruction in the circulation of cerebellum. Cerebral hypoxia caused by ischemia
of the brain gives result in alteration of cells morphology and cell death in which
neuron cells become picnotics. This will later manifests in the form of
neurological disability shown in the affected individuals resulting in the need to
take long term medication. Citicoline is an effective drug for stroke based on
research but has drawbacks in term of usage and high price which cause it to be
less efficient in the community. The herbs cat root and Indian pennywort are
alternative drugs for stroke therapy because of its neuroprotective effects.
Combination dose of these two herbs are expected to provide a change in number
of picnotic cells in rat’s brain.
This research experiments on giving the extract of cat root and indian pennywort
to 5 groups of hypoxic rats in various dose (150, 200, 250 mg of cat root
combined with 150 mg of Indian pennyworts), negative control is given aquades
and positive control is given citicoline. The cerebellum of the rats is then taken
and is made to histopathologic preparation to see the changes of picnotic cells in
gyrus dentatus internus.
From the One Way Anova test results, it can be seen that there is no meaningful
changes in the number of picnotic cells after the treatments are given to the rats
(p>0,05). In conclusion, therapy with combination of cat root and Indian
pennywort does not provide changes in number of picnotic cells in gyrus dentatus
internus of the rats.]
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No. Panggil : S-Pdf
Pengarang :
Pengarang/kontributor lain :
Subjek :
Penerbitan : [Place of publication not identified]: [Publisher not identified], 2013
Program Studi :
Naskah Ringkas : Download Naskah Ringkas
Kode Bahasa : ind
Sumber Pengatalogan : LibUI ind rda
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Deskripsi Fisik : xii, 29 pages : illustration ; 30 cm. + appendix
Catatan Bibliografi : pages 27-29
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
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