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Uji efek hipoglikemik ekstrak etanol 70% buah oyong (Luffa acutangula (L.) Roxb.) terhadap mencit yang dibebani glukosa = Hypoglycemic effect of 70% ethanol extract of ridged gourd fruit (Luffa acutangula (L.) Roxb.) in glucose loaded Mmce

Tan, Jenifer Laurensius; Santi Purna Sari, supervisor; Juheini Amin; Berna Elya, examiner (Universitas Indonesia, 2012)
 Abstrak
[ABSTRAK

Luffa acutangula (L.) Roxb. merupakan tumbuhan yang telah diteliti akan potensi
aktivitas antidiabetesnya di luar Indonesia dan secara empiris telah digunakan di
Indonesia. Tujuan penelitian ini adalah untuk meneliti efek hipoglikemik ekstrak
etanol 70% buah oyong terhadap mencit yang dibebani glukosa. Ekstrak etanol
buah oyong diskrining kandungan fitokimianya dan distandardisasi melalui ciri
organoleptik, kadar fenolat total, kadar abu total dan kadar abu tidak larut dalam
asam, serta susut pengeringan. Dua puluh lima ekor mencit galur ddY
dikelompokkan menggunakan rancangan acak sederhana menjadi 5 kelompok,
yaitu kontrol induksi glukosa, kontrol metformin (sebagai kontrol pembanding),
dan 3 kelompok ekstrak etanol buah oyong (13,35; 26,69; dan 53,38 mg/20 g bb
mencit). Setelah dipuasakan selama 16 jam, semua mencit diberikan bahan uji
yang sesuai lalu dibebani glukosa monohidrat sebesar 2,2 g/kg bb mencit. Kadar
glukosa darah diukur setelah puasa, tiga puluh menit setelah pemberian bahan uji,
dan berturut-turut pada menit ke-30, 60, 90, dan 120 setelah pemberian glukosa
menggunakan glukometer AccuChek Advantage II. Pemberian ekstrak etanol buah
oyong dengan dosis 26,69 dan 53,38 mg/20 g bb mencit dapat menurunkan kadar
glukosa darah yang bermakna pada menit ke-60 dan 90 setelah pemberian glukosa
dengan persentase penurunan kadar glukosa darah sebesar 16-18%.


ABSTRACT

Luffa acutangula (L.) Roxb. is a plant which has been screened for its antidiabetic
potential outside Indonesia and widely used in Indonesia. The aim of this study
was to investigate the hypoglycemic effect of 70% ethanol extract of ridged gourd
in glucose loaded mice. The extract was screened for its phytochemical
constituents and standardized through organoleptic characteristic, total phenolic
content, total ash value and acid insoluble ash value, and loss on drying. Using
simple randomized design, twenty five ddY mice were divided into 5 groups:
glucose induced control, metformin control (as a comparison), and 3 ridged gourd
fruit extract groups (13,35; 26,69; and 53,38 mg/20 g b.w. mouse). After being
fasted for 16 hours, all mice were administered with test samples and loaded with
glucose monohydrate (2,2 g/kg b.w. mouse). Blood glucose concentration was
measured after fasting, thirty minutes after administration, and subsequently at 30,
60, 90, and 120 minutes after glucose load using glucometer AccuChek Advantage
II. Administration of the extract at dose level of 26,69 and 53,38 mg/20 g b.w.
mouse were able to lower blood glucose concentration significantly at 60 and 90
minutes after glucose load with blood glucose concentration lowering percentage
about 16-18%.;Luffa acutangula (L.) Roxb. is a plant which has been screened for its antidiabetic
potential outside Indonesia and widely used in Indonesia. The aim of this study
was to investigate the hypoglycemic effect of 70% ethanol extract of ridged gourd
in glucose loaded mice. The extract was screened for its phytochemical
constituents and standardized through organoleptic characteristic, total phenolic
content, total ash value and acid insoluble ash value, and loss on drying. Using
simple randomized design, twenty five ddY mice were divided into 5 groups:
glucose induced control, metformin control (as a comparison), and 3 ridged gourd
fruit extract groups (13,35; 26,69; and 53,38 mg/20 g b.w. mouse). After being
fasted for 16 hours, all mice were administered with test samples and loaded with
glucose monohydrate (2,2 g/kg b.w. mouse). Blood glucose concentration was
measured after fasting, thirty minutes after administration, and subsequently at 30,
60, 90, and 120 minutes after glucose load using glucometer AccuChek Advantage
II. Administration of the extract at dose level of 26,69 and 53,38 mg/20 g b.w.
mouse were able to lower blood glucose concentration significantly at 60 and 90
minutes after glucose load with blood glucose concentration lowering percentage
about 16-18%., Luffa acutangula (L.) Roxb. is a plant which has been screened for its antidiabetic
potential outside Indonesia and widely used in Indonesia. The aim of this study
was to investigate the hypoglycemic effect of 70% ethanol extract of ridged gourd
in glucose loaded mice. The extract was screened for its phytochemical
constituents and standardized through organoleptic characteristic, total phenolic
content, total ash value and acid insoluble ash value, and loss on drying. Using
simple randomized design, twenty five ddY mice were divided into 5 groups:
glucose induced control, metformin control (as a comparison), and 3 ridged gourd
fruit extract groups (13,35; 26,69; and 53,38 mg/20 g b.w. mouse). After being
fasted for 16 hours, all mice were administered with test samples and loaded with
glucose monohydrate (2,2 g/kg b.w. mouse). Blood glucose concentration was
measured after fasting, thirty minutes after administration, and subsequently at 30,
60, 90, and 120 minutes after glucose load using glucometer AccuChek Advantage
II. Administration of the extract at dose level of 26,69 and 53,38 mg/20 g b.w.
mouse were able to lower blood glucose concentration significantly at 60 and 90
minutes after glucose load with blood glucose concentration lowering percentage
about 16-18%.]
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 Metadata
No. Panggil : S43087
Pengarang :
Pengarang/kontributor lain :
Subjek :
Penerbitan : [Place of publication not identified]: Universitas Indonesia, 2012
Program Studi :
Kode Bahasa : ind
Sumber Pengatalogan : LibUI ind rda
Tipe Konten : text
Tipe Media : unmediated ; computer
Tipe Carrier : volume ; online resources
Deskripsi Fisik : xv, 56 pages : illustration ; 30 cm + appendix
Catatan Bibliografi : pages 52-56
Naskah Ringkas :
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
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No. Panggil No. Barkod Ketersediaan
S43087 TERSEDIA
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